Structural Insights into Competitive Antagonism in NMDA Receptors
Overactive N-methyl-D-aspartate (NMDA) receptors are implicated in several neurological disorders. However, mechanistic understanding of antagonism in NMDA receptors is limited due to a lack of antagonist-bound structures. Here, structures of antagonist-bound ligand-binding domains of NMDA receptors are presented. For more information, see Jespersen et al., Neuron 81(2).
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