Pain Recruits the Kappa Opioid System to Drive Negative Affect
For more information, see Massaly et al., Neuron 102/3, http://www.cell.com/neuron/fulltext/S....
Negative emotional component of pain represents an undertreated burden that can lead to the development of anxiety, depression, and prescription opioid misuse. Here Massaly et al. describe a local circuit governed by the kappa opioid system underlying the negative impact of pain on affective states.
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