BAFF Signalling Pathway | B Cell Maturation and Survival
BAFF is a soluble factor that activates the noncanonical NF-κB pathway, which is a key arm of NF-κB signaling. BAFF provides essential survival signals during B cell maturation.
The NF-κB pathway is a prototypical proinflammatory signaling pathway that plays a critical role in the development, survival, and activation of B lymphocytes. NF-κB is a family of transcription factors that bind the enhancer of the immunoglobulin κ light-chain gene.
The noncanonical NF-κB pathway primarily targets the activation of the p52/RelB NF-κB complex. This pathway depends on the inducible processing of p100, which is both the precursor of p52 and a RelB-specific inhibitor.
BAFF is a critical cytokine that supports the survival of mature naïve B cells. Recent studies show that BAFF and BAFFR are also required for the survival of memory B cells, autoimmune B cells, and malignant chronic lymphocytic leukemia (CLL) cells.
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